Waking up with dry mouth? Here’s what your body might be telling you

Reduce secretions including saliva
Antidepressants (TCAs, SSRIs) Amitriptyline, Fluoxetine, Sertraline Anticholinergic effects suppress salivary glands
Antipsychotics Olanzapine, Clozapine, Haloperidol Strong anticholinergic activity
Blood Pressure Medications Amlodipine, Atenolol, Hydrochlorothiazide Diuretic effect leads to dehydration
Diuretics Furosemide, Spironolactone Increase fluid loss, reducing saliva
Muscle Relaxants Cyclobenzaprine, Baclofen Anticholinergic side effects
Bladder Medications Oxybutynin, Solifenacin Specifically designed to reduce secretions
Parkinson’s Medications Trihexyphenidyl, Benztropine High anticholinergic activity


Important: If you take any of these medications and experience dry mouth, do not stop your medication without medical advice. Speak to your prescribing doctor about